Efficiency of Microbial Enzyme Vs Animal Enzyme

Exocrine Pancreatic Insufficiency (EPI) is a condition where the pancreas produces insufficient enzymes to break down fats, proteins, and carbohydrates. This condition often leaves patients struggling with nutrient absorption (malnutrition) and reduced quality of life.

A recent in vitro study using a dynamic gastrointestinal simulation system, has compared fungal and porcine lipase supplements to address these challenges.

The findings showed how fungal lipases might revolutionize the current treatment:

Efficiency at Lower Dosages:

• Fungal lipases (14,000 units) achieved better fat digestion compared to porcine lipases (20,000 units), showing greater efficiency with fewer enzyme units.

This could mean fewer pills for patients while maintaining effective digestion, a significant advantage for those requiring lifelong therapy.
Activity Across pH Levels:

• Porcine enzymes are optimized for a narrow pH range (5–7), typical of the small intestine. However, in EPI patients, pH variations due to insufficient bicarbonate secretion can affect their effectiveness.
• Fungal lipases remain active across a broader pH range (3–9), retaining functionality even in acidic conditions, such as the stomach.

Advantages in Acidic Environments:

• Low stomach pH often deactivates porcine enzymes, requiring protective enteric coatings to ensure delivery to the intestine.
• Fungal enzymes, active even in acidic environments, bypass this limitation, offering a robust solution for patients with complex digestive conditions.

These findings suggest that fungal lipases could be a game-changer in enzyme replacement therapy. Key advantages include:

• Simplified Treatment: Effective digestion with smaller doses could reduce pill burden for patients.
• Improved Compatibility: Their ability to function in low-pH environments makes fungal lipases suitable for individuals with varying digestive challenges.

While porcine-based therapies have been the primary treatment, this study highlights fungal lipases as a powerful alternative, especially for EPI patients. The ability of fungal enzymes to adapt to complicated digestive conditions could support the way for more effective treatments.